Retinoic acid affects the response of v-Myb-transformed monoblasts to okadaic acid

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Authors

BENEŠ Petr MACEČKOVÁ Vendula ANDRYSÍK Zdeněk ZATLOUKALOVÁ Jiřina ŠMARDA Jan

Year of publication 2006
Type Article in Proceedings
Conference Haematologica/the hematology journal
MU Faculty or unit

Faculty of Science

Citation
Field Genetics and molecular biology
Keywords okadaic acid; retinoic acid; differentiation; apoptosis; monoblast; v-Myb
Description The aim of this study was to explore the functional interaction of retinoic acid (RA)- and okadaic acid (OA)-driven pathways in v-Myb-transformed monoblasts BM2. We found that 10 nm OA induces adherency, cell cycle arrest, phagocytic activity, production of reactive oxygen species, and expression of vimentin in BM2 cells. These features that mark differentiation along monocyte/macrophage pathway are enhanced in BM2 cells upon simultaneous treatment with OA and RA. Interestingly, the 20 nm OA induces rather apoptosis than differentiation of BM2 cells. This pro-apopotic effect of OA was inhibited by RA. These results indicate that pro-differentiation and pro-apoptotic effects of OA on BM2 monoblasts are differently regulated by RA.
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