Role of genetic variability in antioxidant and DNA reparation enzymes in diabetic nephropathy
| Authors | |
|---|---|
| Year of publication | 2006 |
| Type | Article in Periodical |
| Magazine / Source | Diabetologia |
| MU Faculty or unit | |
| Citation | |
| Field | Endocrinology, diabetology, metabolism, nutrition |
| Keywords | diabetes mellitus; nephropathy; oxidative stress |
| Description | Diabetic nephropathy (DN) develops as a result of hemodynamic and metabolic changes accompanying diabetes. Hyperglycemia-induced overproduction of reactive oxygen species (ROS) is an important pathogenic determinant of DN. (In)efficient cellular protection by antioxidant enzymes is reflected in the overall extent of oxidative damage. Genetic variability in genes encoding antioxidant enzymes belong to functional candidates potentially modulating susceptibility to DN. Subsequently, oxidative DNA damage due to ROS overproduction activates DNA reparation. Unfortunately, this further aggravates cellular dysfunction/damage due to consumption of energy substrates and metabolic cofactors. The aim of the study was to investigate relationship between genetic variability in genes encoding poly-(ADP-ribose) polymerase (ADPRT), manganese superoxide dismutase (SOD2), catalase (CAT), glutathione S-transferases (GST) and susceptibility to DN. |
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