Effect of haloperidol on transient outward potassium current in rat ventricular myocytes

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Authors

BÉBAROVÁ Markéta MATEJOVIČ Peter PÁSEK Michal NOVÁKOVÁ Marie

Year of publication 2006
Type Article in Periodical
Magazine / Source European Journal of Pharmacology
MU Faculty or unit

Faculty of Medicine

Citation
Field Physiology
Keywords haloperidol; transient outward current; sigma receptors; rat ventricular myocytes; whole-cell pach clamp; quantitative model
Description Haloperidol induced a decrease of amplitude and an acceleration of apparent inactivation of transient outward potassium current (Ito), both in a voltage-dependent manner. The averaged inhibition of Ito, evaluated as a change of its time integral, was 23.0 +/- 3.2% at stimulation frequency of 0.1 Hz. As a consequence of slow recovery of Ito from the haloperidol-induced block (time constant 1482 +/- 83 ms), a cumulation of the block up to about 40% appeared at 3.3 Hz.
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