Behavioural and immune effects of cannabidiol in a mouse model of bilateral olfactory bulbectomy

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Authors

PISTOVČÁKOVÁ Jana ŠULCOVÁ Alexandra KELLY John LEONARD Brian

Year of publication 2006
Type Article in Periodical
Magazine / Source The International Journal of Neuropsychopharmacology
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords cannabidiol; mice; depression; olfactory bulbectomy
Description The study tested an antidepressant effect of cannabidiol (CBD) in olfactory bulbectomized (OB) mice, a well-established animal model of depression resembling behavioural, immune and endocrine changes. CBD did not show antidepressant behavioural properties in this animal model. This can discussed in relation to our previous results in social defeat mouse model, where CBD appeared to elicit anxiolytic activity. Reversal of the suppressed leukocyte phagocytosis in the OB mice by CBD correlates with the stimulatory effect of cannabinoids reffered in the literature.
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