The influence of gender and administration of bupropion on the activity of hepatic CYP 450 2D2 in rats

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Authors	ZENDULKA Ondřej ZAHRADNÍKOVÁ Lucia JUŘICA Jan HADAŠOVÁ Eva
Year of publication	2006
Type	Article in Proceedings
Conference	Collegium Internationale Neuro-Psychopharmacologicum, Final Program and Book of Abstracts.
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	cytochrom P 450 bupropion
Description	We observed different activity of selected CYP 450 isoenzymes due to gender and administration of antidepressant bupropion. CYP 2D2 activity in higher in female rats and activities of CYP 2C6 and 1A2 were higher in males than in females.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.