HPLC STANOVENÍ MIDAZOLAMU A JEHO METABOLITŮ V PLAZMĚ A PERFUZNÍM MEDIU

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Title in English HPLC determination of midazolam and its metabolites in plasma and perfuse medium
Authors

JUŘICA Jan TOMANDL Josef DOSTÁLEK Miroslav ZAHRADNÍKOVÁ Lucia ZENDULKA Ondřej HADAŠOVÁ Eva

Year of publication 2006
Type Article in Proceedings
Conference Zborník vedeckých prác XIV. medzinárodné konferencie Chromatografické metódy a zdravie človeka
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords HPLC; determination; CYP3A; midazolam
Description The presented HPLC isocratic method allows to determine midazolam and its three hydroxylated metabolites in plasma and perfusion medium. This method is suitable for modeling and description of possible pharmacological interactions on isoform CYP3A4/5.
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