Association of eNOS gene polymorphisms T-786C and G894T with blood pressure variability
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| Year of publication | 2006 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Association of single nucleotide polymorphisms (SNPs) T-786C and G894T in gene encoding eNOS with blood pressure variability (BPV) in man was evaluated. Systolic and diastolic blood pressure variability in relative and absolute units were determined in 129 healthy subjects by spectral method as spectral power at the frequency of 0.1 Hz. Genotypes were detected by means of polymerase chain reaction and restriction analysis. Carriers of less frequent alleles showed significantly greater BPV comparing more frequent alleles homozygotes. The determined SNPs were in linkage disequilibrium. Carriers of genotype CC (for T-786C) with TT (for G894T) displayed significantly greater BPV compared to carriers of other genotype combinations. We found significant associations of T-786C and G894T polymorphisms in gene encoding eNOS with systolic and diastolic blood pressure variability. Less frequent alleles of T-786C and G894T in gene encoding eNOS are associated with increased systolic and diastolic BPV. |
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