Blood Pressure and Baroreflex Sensitivity after Anthracycline Chemotherapy in Childhood with Respect to Fatty Acid Metabolism
| Authors | |
|---|---|
| Year of publication | 2005 |
| Type | Article in Periodical |
| Magazine / Source | Scripta medica |
| MU Faculty or unit | |
| Citation | |
| Field | Physiology |
| Keywords | Anthracycline; Blood pressure; Baroreflex sensitivity; Heart rate variability; Cholesterol |
| Description | Late effects of caardiotoxic therapy on childhood cancer were studied. Body and circulation parameters were compared in 206 helathy controls, and 97 children and adolescents after antitumour treatment at the age of 11 - 21 years with respect to plasma lipid level. The subjects after antitumour therapy had increased parasympathetic and decreased sympathetic tonic activity together with decreased baroreflex sensitivity. The increase of inter-beat interval variability was neither the result of a primary increase of vasomotor activity nor an increase of baroreflex sensitivity response to changes in blood pressure. We can explain it by increasing parasympathetic control of the heart. The circulatory changes did not bear on obesity, but they were rather a specific effect of tumour disease and antitumou treatment. |
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