Role of cannabinoid CB1 receptor inhibition in regulation of anxiety and depression related behaviours in mice

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Authors

ŠULCOVÁ Alexandra PISTOVČÁKOVÁ Jana

Year of publication 2007
Type Article in Proceedings
Conference Programme and Abstracts, 9th International Neuroscience Winter Conference
MU Faculty or unit

Faculty of Medicine

Citation
Field Pharmacology and pharmaceutical chemistry
Keywords CB1 receptor antagonists; anxiety; depression; mice
Description Two CB1 receptor antagonists rimonabant and AM251 showed just tendency to increase aggressive activities mice, without any other significant behavioural changes in the timid mice, that means no anxiolytic effects. However, our findings confirmed that rimonabant may have a suggested beneficial effect on depression and social stress-related behaviour.
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