Retinoic acid enhances differentiation of v-myb-transformed monoblasts induced by okadaic acid
| Authors | |
|---|---|
| Year of publication | 2007 |
| Type | Article in Periodical |
| Magazine / Source | Leukemia Research |
| MU Faculty or unit | |
| Citation | |
| Field | Genetics and molecular biology |
| Keywords | v-myb; monoblast; macrophage; differentiation; okadaic acid; retinoic acid; protein phosphatase |
| Description | Differentiation of various leukemic cells can be induced by liganded retinoic acid receptors and phosphatase inhibitors. In this study, we explored the effects of okadaic acid (OA), the phosphatase inhibitor, and retinoic acid (RA) in v-myb-transformed monoblasts BM2. OA induced differentiation of BM2 cells into macrophage-like cells. In contrast to many other leukemic cell lines, BM2 cells do not respond to RA. However, once exposed to OA and RA simultaneously, BM2 cells differentiate alone monocyte/macrophage pathway more efficiently. We conclude that RA enhances differentiation of v-myb-transformed monoblasts induced by protein phosphorylation. |
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