Assessment of retinoic toxicity in several types of complex environmental samples using P19/A15 cell line

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Authors	NOVÁK Jiří BENÍŠEK Martin ŠTĚPÁNKOVÁ Tereza BLÁHA Luděk GIESY John Paul HILSCHEROVÁ Klára
Year of publication	2006
Type	Conference abstract
MU Faculty or unit	Faculty of Science
Citation
Description	The retinoic signaling pathway could be one of the important targets for endocrine disruptors because of the fact that retinoids control large number of vital processes in the organism and that their signaling is very complexly regulated. We developed an in vitro model for evaluation of anti/retinoic action of xenobiotics. The model is based on murine embryonic carcinoma cell line P19, which retains its pluripotent character so that it is able to differentiate into cells of the all three germ layers.
Related projects:	Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL) In vitro models for study of endocrine disruption - effects of traditional and new types of persistent organic pollutants