Effect of methamphetamine on cytochrome P450 activity.

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Authors	DOSTÁLEK Miroslav JUŘICA Jan PISTOVČÁKOVÁ Jana HANESOVÁ Mariana TOMANDL Josef LINHART I. ŠULCOVÁ Alexandra
Year of publication	2007
Type	Article in Periodical
Magazine / Source	Xenobiotica
MU Faculty or unit	Faculty of Medicine
Citation
Field	Pharmacology and pharmaceutical chemistry
Keywords	Merhamphetamine; CYP450
Description	The effect of methamphetamine pretreatment (10 mg kg(-1), intraperitoneally once daily for 6 days) on the activity of the P450 enzymes was assessed both in the rat isolated perfused liver and in vivo. Stimulatory effect on P4502C6 was recorded.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.