Effect of ferB mutation on the sensitivity of Paracoccus denitrificans to quinones

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Authors	SEDLÁČEK Vojtěch KUČERA Igor VAN SPANNING Rob
Year of publication	2007
Type	Article in Proceedings
Conference	FEBS Journal Supplement 32nd FEBS Congress Abstracts
MU Faculty or unit	Faculty of Science
Citation
Field	Biochemistry
Keywords	quinone; reductase; stoichiometry; redox cycling
Description	By using insertional mutagenesis, we have demonstrated that a putative quinone reductase encoded by the ferB gene confers increased susceptibility to 1,4-naphthoquinones, but not to 1,4-benzoquinones. This difference may be due to a one-electron reduction of naphthoquinones to reactive radical semiquinones and subsequent generation of oxygen reactive species.
Related projects:	Proteins in metabolism and interaction of organisms with the environment Structure, function and regulation of FerB, a broad-specificity bacterial oxidoreductase of a potential ecotechnological relevance