Effect of ferB mutation on the sensitivity of Paracoccus denitrificans to quinones

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Authors

SEDLÁČEK Vojtěch KUČERA Igor VAN SPANNING Rob

Year of publication 2007
Type Article in Proceedings
Conference FEBS Journal Supplement 32nd FEBS Congress Abstracts
MU Faculty or unit

Faculty of Science

Citation
Field Biochemistry
Keywords quinone; reductase; stoichiometry; redox cycling
Description By using insertional mutagenesis, we have demonstrated that a putative quinone reductase encoded by the ferB gene confers increased susceptibility to 1,4-naphthoquinones, but not to 1,4-benzoquinones. This difference may be due to a one-electron reduction of naphthoquinones to reactive radical semiquinones and subsequent generation of oxygen reactive species.
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