Determination and utilization of drugs as markers of metabolic activity of cytochrome P450 (invited lecture)

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Authors

TOMANDL Josef JUŘICA Jan DOSTÁLEK Miroslav

Year of publication 2007
Type Appeared in Conference without Proceedings
MU Faculty or unit

Faculty of Medicine

Citation
Description Lecture summarises our experiences with drugs as markers of metabolic activity of cytochrome P450. There are presented methods for the determination of phenacetine and its O-deethylation product (marker of CYP1A2 activity); diclofenac and tolbutamide and its hydroxylation metabolites (markers of CYP2C9); midazolam, nifedipine and dextromethorphan and their metabolites (marker of CYP3A) and dextromethorphan as a marker in O-demethylation reaction for CYP2/6. For drug determinations were developed HPLC methods based on a reverse-phase separation with UV or fluorescent of coulochemical detection. The methods were applied in farmacokinetic studies and some results will be discused.
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