Citlivost baroreflexu a polymorfismus A1166C v genu pro AT1 receptor

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Title in English	Baroreflex Sensitivity And A1166C Polymorphism In AT1 Receptor Gene
Authors	JÍRA Miroslav ZÁVODNÁ Eva HONZÍKOVÁ Nataša NOVÁKOVÁ Zuzana VAŠKŮ Anna IZAKOVIČOVÁ HOLLÁ Lydie FIŠER Bohumil
Year of publication	2007
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	Decreased baroreflex sensitivity (BRS in ms/mmHg; BRSf in mHz/mmHg) contributes to the development of hypertension and to the risk of sudden cardiac death in patients after myocardial infarction. The aim of this study was to evaluate association of single nucleotide polymorphism A1166C in angiotensin II type 1 receptor (AT1R) gene with BRS and BRSf in man. We found significant association of A1166C polymorphism in AT1 receptor gene with baroreflex sensitivity. Less frequent allele was associated with decreased BRS and BRSf.
Related projects:	Early diagnostics and treatment of cardiovascular diseases