Comparison of Dendritic Cells in Healthy Volunteers and Subjects with Monoclonal Gammopathy and/or Multiple Myeloma

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Authors

KOVÁŘOVÁ Lucie OČADLÍKOVÁ Darina MICHÁLEK Jaroslav PENKA Miroslav HÁJEK Roman

Year of publication 2007
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Dendritic cells are highly specialised antigen-presenting cells, which can be used for immunotherapy trials. Functionally normal DCs play a critical role in the activation and potentiation of tumour antigen-specific responses, but in some cases they can be defective. The aim of study were analysis of phenotype, finding of differences and/or functional defects in DCs generated from multiple myeloma and monoclonal gammopathy of unknown significance subjects when compared with healthy volunteers under serum-free and/or autologous conditions.
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