The combined effect of ultrasound exposure and cisplatin on human ovarian carcinoma cells A2780

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Authors

BERNARD Vladan ŠKORPÍKOVÁ Jiřina MORNSTEIN Vojtěch

Year of publication 2008
Type Article in Periodical
Magazine / Source Folia Biologica (Praha)
MU Faculty or unit

Faculty of Medicine

Citation
Field Biophysics
Keywords cisplatin; cytotoxicity; ovarian carcinoma cells A2780; ultrasound
Description It was shown that a combined effect of ultrasound and cisplatin was more effective than that of ultrasound or cisplatin alone. It also appeared that the order of application played a role, with the cisplatin-ultrasound treatment lowering cell viability more than the ultrasound-cisplatin treatment. It can be assumed that the exposure of cells to a low-power ultrasonic field has an immediate effect on the structure of cell surfaces and, consequently, on entry of cisplatin into the cell.
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