Diabetická nefropatie- renální funkce a hladina sRAGE, genet. variabilita AGER genu

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Title in English	Diabetic nephropathy, renal function, level of soluble RAGE and genetic variability in the AGER gene
Authors	KRUSOVÁ Darja KAŇKOVÁ Kateřina KALOUSOVÁ Marta HERTLOVÁ Miluše ZIMA Tomáš
Year of publication	2008
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	Diabetic nephropathy (DN) is associated with accumulation of Advanced Glycation End products (AGEs) exerting their adverse effects via Receptor of AGE (RAGE). Soluble RAGE (sRAGE) is a truncated form of RAGE functioning as an inhibitor of AGE-mediated signalling. In our study, GFR is a principal determinant of sRAGE concentration and gradual sRAGE increase in subjects with advancing impairment of renal function is paralleled by AGEs. ). sRAGE did not correspond with carrier state of risk-haplotype copies (RAGE2).
Related projects:	Functional analysis of the RAGE gene susceptibility haplotype and its role in the hyperglycemia-driven pathology