Stanovení fenotypu CYP2D6 u psychiatrických pacientů - možnosti a souvislosti.

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Title in English	Phenotype determination of CYP2D6 in psychiatric patients - possibilities and implications.
Authors	JUŘICA Jan ŽOURKOVÁ Alexandra FLODROVÁ Eva MCCASKEY HADAŠOVÁ Eva
Year of publication	2008
MU Faculty or unit	Faculty of Medicine
Citation
Description	Possibilities of CYP2D6 phenotype and genotype determination in psychiatric patients were discussed. Then, the the influence of phenotype of CYP2D6 on clinical response was evaluated (patients with anxiety disorder on paroxetine treatment; n=16). Influence of phenotype on the adverse effects occurence was evaluated as well (including sexual dysfunctions) in the long term paroxetine treatment(patients treated with paroxetine for more than 3 months; n=50).
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.