Phenotype of plasma cells in monoclonal gammopathy of undetermined significance and multiple myeloma subjects
| Authors | |
|---|---|
| Year of publication | 2008 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | The aim of this study was to find possibilities and limits of multicolour flow cytometry in diagnostics of monoclonal gammopathies and to evaluate whether or not the expression of CD19 and CD56 can distinguish between normal polyclonal and abnormal clonal PCs. Lower number of PCs was found in MGUS patients when compared with MM patients and these PCs can be separated into subpopulations including normal residual CD19+CD56- PCs and abnormal CD56+CD19- (alternatively CD56+CD19+ or CD56-CD19- in MM cases) PCs. Surface marker CD19 is a useful parameter for identification of normal residual PCs, but assessment of light chain restriction is recommended for verification of their normality, especially in MM cases. |
| Related projects: |