Přínos fenotypizace plazmocytů v diagnostice mnohočetného myelomu a monoklonální gamapatie nejasného významu

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Title in English Plasma cells phenotypisation in diagnostics of multiple myeloma and monoclonal gammopathy of undetermined significance
Authors

KOVÁŘOVÁ Lucie BUREŠOVÁ Ivana SUSKÁ Renata POUR Luděk ZAHRADOVÁ Lenka PENKA Miroslav HÁJEK Roman

Year of publication 2008
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Monoclonal gammopathy of undetermined significance (MGUS) is an asymptomatic plasma cells (PCs) disorder, which can eventually progress into malignant multiple myeloma (MM). Multicolour flow cytometry is a sensitive tool for the analysis of number and clonality of PCs in these monoclonal gammopathies. The aim of this study was to analyse plasma cells (PCs) in MGUS and MM patients and to find parameter which can distinguish between them. PCs were identified as CD38+CD138+ cells and expression of CD19 and CD56 was used for discrimination of normal (N-PCs) and abnormal (A-PCs) PCs, respectively. Analysis of light chain restiction was done in selected cases. Flow cytometry is a sufficiently sensitive method for analysis of N-PCs (CD19+CD56- PCs) and abnormal A-PCs (CD56+CD19-, CD56+CD19+ or CD56-CD19-), even in low infiltration of bone marrow. Relative number of CD19+ PCs is an useful parameter for discrimination of MGUS from all clinical stages of MM.
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