Morphology of fronto-temporal Regions and Word Generation in First-episode Schizophrenia
| Title in English | Morphology of Fronto-temporal Regions and Word Generation in First-episode Schizophrenia |
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| Authors | |
| Year of publication | 2008 |
| Type | Article in Periodical |
| Magazine / Source | Activitas Nervosa Superior |
| MU Faculty or unit | |
| Citation | |
| Field | Psychiatry, sexuology |
| Keywords | voxel based morphometry; schizophrenia; FT dysfunction; verbal fluency task |
| Description | Fronto temporal (FT) dysfunction is a characteristic feature of schizophrenia. We tried to find features of brain morphology that are connected with the solving of Verbal Fluency Task (VFT). We hypothesized that verbal fluency results correlate positively with gray and white matter volume in fronto temporal areas. 25 first episode schizophrenia men were tested using Correlations between VFT score and brain morphology were performed using General linear mode - regression analysis. There was a significant positive correlation of regional gray matter and VFT score in the posterior part of superior temporal gyrus, on the borders with middle temporal gyrus and inferior parietal lobule. As for the regional white matter volume there was one significant cluster in the depth of the inferior frontal gyrus, pars triangularis. The ability to neerate context appropriate words is not only the result of abnormal FT co-operation or ability to "hire" prefrontal activity when necessary, but also stems from the condition of relevant neuronal networks. |
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