Schnitzlerův syndrom - popis čtrnáctiletého průběhu nemoci a přehled informací o této nemoci.

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Title in English Schnitzler syndrome-report on a fourteen-year course of the disease and an overview of information on the disease
Authors

ADAM Zdeněk KREJČÍ Marta POUR Luděk NEUBAUER J. PRÁŠEK J. HÁJEK Roman

Year of publication 2008
Type Article in Periodical
Magazine / Source Vnitřní lékařství
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords Schnitzler syndrome
Description Schnitzler syndrome is a rare disease characterised by chronic urticaria and the presence of monoclonal IgM immunoglobulin, and by other symptoms. We report ourexperience with 14-year treatment of a patient. In the course of 14 years, we confirmed partial therapeutic effect of glucocorticoids administered on a continuous basis, as well as a partial therapeutic effect of interferon alpha, thalidomide and PUVA, but all the therapies had to be discontinued due to adverse effects. A major turn, i.e. the complete disappearance of skin symptoms and normalisation of CRP and haemoglobin values, only came with anakinra which has become the drug of the first choice for the above syndrome.
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