Interference with hormonal signaling and dioxin-like activity elicited by pollutants in particulate and gaseous air fractions

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Authors

NOVÁK Jiří JÁLOVÁ Veronika GIESY JP HILSCHEROVÁ Klára

Year of publication 2009
Type Article in Periodical
Magazine / Source Environment International
MU Faculty or unit

Faculty of Science

Citation
Field Air pollution and control
Keywords air; endocrine disruption; dioxin-like toxicity; antiestrogenic; antiandrogenic
Description Interference with hormonal signaling and dioxin-like activity elicited by pollutants in particulate and gaseous air fractions. Traditionally, contamination of air has been evaluated primarily by chemical analyses of indicator contaminants and these studies have focused mainly on compounds associated with particulates. Some reports have shown that air contaminants can produce specific biological effects such as toxicity mediated by the aryl hydrocarbon receptor (AhR) or modulation of the endocrine system. This study assessed the dioxin-like toxicity, anti/estrogenicity, anti/androgenicity and anti/retinoic activity of both the particulate and gas phase fractions of air in two regions with different types of pollution sources and a background locality situated in an agricultural area of Central Europe.
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