High molecular weight FGF2: the biology of a nuclear growth factor

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Authors

CHLEBOVÁ Katarína BRYJA Vítězslav DVOŘÁK Petr KOZUBÍK Alois WILCOX W.R. KREJČÍ Pavel

Year of publication 2009
Type Article in Periodical
Magazine / Source Cellular and molecular life sciences : CMLS
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1007/s00018-008-8440-4
Field Genetics and molecular biology
Keywords FGF2; fibroblast growth factor;nuclear; signalling; Api5; SMN
Description Fibroblast growth factor 2 (FGF2) is one of the most studied growth factors to date. Most attention has been dedicated to the smallest, 18 kDa FGF2 variant that is released by cells and acts through activation of cell-surface FGF-receptor tyrosine kinases. There are, however, several higher molecular weight (HMW) variants of FGF2 that rarely leave their producing cells, are retained in the nucleus and act independently of FGF-receptors (FGFR). Despite significant evidence documenting the expression and intracellular trafficking of HMW FGF2, many important questions remain about the physiological roles and mechanisms of action of HMW FGF2. In this review, we summarize the current knowledge about the biology of HMW FGF2, its role in disease and areas for future investigation.
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