Expression of CD27 on plasma cells in monoclonal gammopathies
| Authors | |
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| Year of publication | 2009 |
| Type | Conference abstract |
| MU Faculty or unit | |
| Citation | |
| Description | Multiple myeloma (MM) is characterised by a clonal expansion of neoplastic plasma cells (PC). These PCs are mostly CD19-CD56+, but in a small group of patients clonal CD19+ PCs occur. The aim of this study was to analyse expression of CD27 on CD19+ PCs in different groups of MM patients and to prove that CD27 can be routinely used to confirm polyclonality of CD19+ PCs. In group of 5 patients with clonal CD19+ PCs was the correlation between median of CD19+CD56- PCs and CD19+CD27+ PCs significantly lower (0.36) than in group 55 patients with polyclonal CD19+ PCs (0.96). In our hands expression of CD27 on CD19+ PCs can discriminate between clonal and polyclonal CD19+ PCs and thus can be potentially used instead of labour intensive light chains assessment. |
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