Levels of angiogenic factors in patients with multiple myeloma correlate with treatment response

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Authors

POUR Luděk ŠVÁCHOVÁ Hana ADAM Zdeněk ALMÁŠI Martina BUREŠOVÁ Ivana BÜCHLER Tomáš KOVÁŘOVÁ Lucie NĚMEC Pavel PENKA Miroslav VORLÍČEK Jiří HÁJEK Roman

Year of publication 2010
Type Article in Periodical
Magazine / Source Annals of Hematology
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords multiple myeloma; angiogenesis; cytokines
Description Angiogenesis plays a significant role in the pathogenesis of multiple myeloma (MM). We have measured concentrations of angiogenesis activators, including vascular endothelial growth factor (VEGF), basic fibroblast growth factor, and hepatocyte growth factor (HGF), and inhibitors, including endostatin, thrombospondin-1 (TSP-1), and angiostatin in the peripheral and bone marrow blood of MM patients at diagnosis and after high-dose chemotherapy.
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