Individual myeloma specific T-cell clones eliminate tumour cells and correlate with clinical outcomes in patients with multiple myeloma

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Authors

MICHÁLEK Jaroslav OČADLÍKOVÁ Darina MATĚJKOVÁ Eva FOLTÁNKOVÁ Veronika DUDOVÁ Silvie SLABÝ Ondřej HORVÁTH Radek POUR Luděk HÁJEK Roman

Year of publication 2010
Type Article in Periodical
Magazine / Source British Journal of Haematology
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords multiple myeloma; T lymphocyte; clonality
Description We developed an ex vivo strategy for inducing myeloma-specific cytotoxic T lymphocytes (CTLs) and demonstrate the possibility of identification and long-term in vivo monitoring of individual myeloma-specific T-cell clones using the most sensitive clonotypic assay that is able to detect low frequencies of T-cell clones (1 clonotypic cell in 10(6) cells). We conclude that the clonotypic assay is the most sensitive tool for immunomonitoring of low-frequency T cells.
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