Lack of Population Diversity in Human Embryonic Stem-Cell Lines

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Authors

MOSHER Jack T PEMBERTON Trevor J HARTER Kristina WANG Chaolong BUSBAS Erkan O DVOŘÁK Petr SIMÓN Carlos MORRISON Sean J ROSENBERG Noah A

Year of publication 2009
Type Article in Periodical
Magazine / Source New England Journal of Medicine
MU Faculty or unit

Faculty of Medicine

Citation
Field Genetics and molecular biology
Keywords human embryonic stem cell; population diversity
Description We determined the genetic ancestry of large collection of stem-cell lines. We have found that widely distributed stem-cell lines lack population diversity and that none of these lines derive from populations with recent African ancestry. Efforts to derive and disseminate new stem-cell lines should now emphasize underrepresented pupulations, to allow researchers to assess the extent to which the ancestry of stem-cell lines influences diesease models, cellular therapies, and drug screening with the use of stem cells.
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