Centrosome amplification as a possible marker of mitotic disruptions and cellular carcinogenesis in multiple myeloma

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Authors

DEMENTYEVA Elena Vladimirovna NĚMEC Pavel KRYUKOV Fedor MUTHU RAJA Karthick Raja SMETANA Jan ZAORALOVÁ Romana GREŠLIKOVÁ Henrieta KUPSKÁ Renata KUGLÍK Petr HÁJEK Roman

Year of publication 2010
Type Article in Periodical
Magazine / Source Leukemia Research
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords Multiple myeloma; B-cells; Plasma cells; Centrosome amplification
Description Centrosome amplification (CA) as a potential marker of mitotic disruptions in multiple myeloma (MM) was investigated in two populations of B-cell lineage: B-cells and plasma cells (PCs). There was no significant correlation between CA-positive MM cases (based on PC samples evaluation) and the occurrence of cytogenetic abnormalities in PCs, including del(13)(q14), del(17)(p13), gain(1)(q21) and hyperdiploidy.
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