Inhibition of gap-junctional intercellular communication and activation of mitogen-activated protein kinases by cyanobacterial extracts - Indications of novel tumor-promoting cyanotoxins?

Warning

This publication doesn't include Faculty of Arts. It includes Faculty of Science. Official publication website can be found on muni.cz.

Authors	BLÁHA Luděk BABICA Pavel HILSCHEROVÁ Klára UPHAM B.
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Toxicon
MU Faculty or unit	Faculty of Science
Citation
Doi	http://dx.doi.org/10.1016/j.toxicon.2009.07.009
Field	Environment influence on health
Keywords	GJIC; MAPK; cyanobacteria
Description	Extracts of cyanobacteria (laboratory cultures of Microcystis aeruginosa and Aphanizomenon flos-aquae and water blooms dominated by these species) inhibited GJIC and activated MAPKs in a dose-dependent manner (effective concentrations ranging 0.5-5 mg d.w./mL). Effects were independent of the microcystin content and the strongest responses were elicited by the extracts of Aphanizomenon sp.
Related projects:	Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL) Tumor promotional mechanisms of cyanobacterial metabolites