Inhibition of gap-junctional intercellular communication and activation of mitogen-activated protein kinases by cyanobacterial extracts - Indications of novel tumor-promoting cyanotoxins?

Investor logo

Warning

This publication doesn't include Faculty of Arts. It includes Faculty of Science. Official publication website can be found on muni.cz.
Authors

BLÁHA Luděk BABICA Pavel HILSCHEROVÁ Klára UPHAM B.

Year of publication 2010
Type Article in Periodical
Magazine / Source Toxicon
MU Faculty or unit

Faculty of Science

Citation
Doi http://dx.doi.org/10.1016/j.toxicon.2009.07.009
Field Environment influence on health
Keywords GJIC; MAPK; cyanobacteria
Description Extracts of cyanobacteria (laboratory cultures of Microcystis aeruginosa and Aphanizomenon flos-aquae and water blooms dominated by these species) inhibited GJIC and activated MAPKs in a dose-dependent manner (effective concentrations ranging 0.5-5 mg d.w./mL). Effects were independent of the microcystin content and the strongest responses were elicited by the extracts of Aphanizomenon sp.
Related projects:

You are running an old browser version. We recommend updating your browser to its latest version.