An unusual loss of EGFR gene copy in glioblastoma multiforme in a child: a case report and analysis of a successfully derived HGG-02 cell line
| Authors | |
|---|---|
| Year of publication | 2010 |
| Type | Article in Periodical |
| Magazine / Source | Child's Nervous System |
| MU Faculty or unit | |
| Citation | |
| Field | Oncology and hematology |
| Keywords | glioblastoma multiforme; EGFR ; p53; FISH; FASAY; karyotyping |
| Description | This study report on a case of glioblastoma multiforme with a polyploid karyotype including a very unusual genetic change - the loss of a copy of the EGFR gene at locus 7p11.2 (EGFR gene) - diagnosed in a 14.5-year-old boy. To date, this patient has survived event-free for 34 months. A detailed analysis of the HGG-02 cell line, which was derived from this primary tumor, was also performed. |
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