Molekulární patogeneze chronické lymfocytární leukemie

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Title in English Molecular pathogenesis of chronic lymphocytic leukemia
Authors

MRÁZ Marek PAVLOVÁ Šárka MALČÍKOVÁ Jitka PLEVOVÁ Karla MAYER Jiří POSPÍŠILOVÁ Šárka

Year of publication 2010
Type Article in Periodical
Magazine / Source Transfuze a hematologie dnes
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords chronic lymphocytic leukemia; CLL; molecular pathogenesis
Description In recent years, treatment approaches for chronic lymphocytic leukemia (CLL) partially improved including evaluation of their efficiency by MRD-negativity. However, the pathogenesis of CLL has not been clearly elucidated and this unables the development of more effective treatment strategies for unfavourable disease subtypes. The studies of CLL biology point to three major areas with pathogenetic relevance: BCR signaling, apoptotic defects and influence of the microenvironment. Moreover, the CLL biology is complicated by partially different history of the subtypes and their relation to variable prognosis and novel therapeutic compounds.
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