Expression of RAN, ZHX-2, and CHC1L genes in multiple myeloma patients and in myeloma cell lines treated with HDAC and Dnmts inhibitors.

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Authors

LEGARTOVÁ Soňa HARNIČAROVÁ-HORÁKOVÁ Andrea BÁRTOVÁ Eva HÁJEK Roman POUR Luděk KOZUBEK Stanislav

Year of publication 2010
Type Article in Periodical
Magazine / Source Neoplasma
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.4149/neo_2010_05_482
Field Oncology and hematology
Keywords multiple myeloma; real time PCR; MOLP-8; RAN; ZHX-2; CHC1L
Description Real time PCR is a powerful tool for studying the expression of genes involved in the pathophysiology of human diseases. Here, we described a detailed Real-Time PCR method for the detection of RAN, ZHX-2, and CHC1L expression, which could be applied in clinical situations. The expression profiles of these genes were studied in peripheral blood lymphocytes of healthy individuals, patients suffering from MM, and in the myeloma cell line, MOLP-8. Our experiments illustrate new methodological approaches and troubleshooting for conducting gene expression studies in clinical laboratories.
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