Polymorphisms in the IL-10 promoter region and microbial composition in patients with chronic and aggressive periodontitis

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Authors	IZAKOVIČOVÁ HOLÁ Lydie HRDLIČKOVÁ Barbara BUČKOVÁ Dana VOKURKA Jan AUGUSTÍN Peter FASSMANN Antonín
Year of publication	2010
Type	Conference abstract
MU Faculty or unit	Faculty of Medicine
Citation
Description	Interleukin-10 (IL-10) is a key regulatory cytokine that has a significant effect on both the innate and adaptive immune response. It may be of significance in the chronic inflammatory diseases such as periodontitis and IL-10 gene haplotypes are known to be associated with the variation of IL-10 production. The aim of this study was to analyze polymrophisms in the IL-10 gene and their associations with microbial composition and clinical manifestation of chronic (CP) or aggressive (AgP) periodontitis.
Related projects:	Dental research centre