Odlišné průběhy recidivující anebo multisystémové formy histiocytózy z Langerhansových buněk u dospělých osob - popis 22 případů z jednoho pracoviště

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Title in English Different courses of recurrent or multisystem Langerhans cells histiocytosis in adults--description of 22 cases from one centre
Authors

ADAM Zdeněk KREJČÍ Marta POUR Luděk SZTURZ Petr NEUBAUER J. NEBESKÝ T. ŘEHÁK Z. KOUKALOVÁ R. MAYER Jiří VORLÍČEK Jiří

Year of publication 2010
Type Article in Periodical
Magazine / Source Vnitřní lékařství
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords Langerhans cell histiocytosis
Description Since its establishment in 1990, a total of 22 patients with confirmed Langerhans cell histiocytosis (LCH) have been monitored and treated at the Clinic of Internal Medicine Haemato-Oncology in Brno. In 5 patients, the disease was diagnosed in childhood and 2 of these 5 patients had late neurodegenerative changes in the CNS with a typical picture on MR and a typical PET-CT imaging fluorodeoxyglucose hypometabolism in the cerebellar area. In 5 patients from the cohort of 22, the disease had unifocal form, dominant in the area of skeleton with no recurrence after the treatment. However, in 12 patients, the disease affected a number of organs simultaneously (multifocal form of LCH). The aim of the description below is to characterise the monitored cohort of 22 patients and describe the very different courses of multifocal forms of LCH in 12 patients.
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