Anthracycline therapy and 24-hour blood-pressure profile in long-term survivors of childhood cancer

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Authors

NOVÁKOVÁ Zuzana ŠŤASTNÁ Jana HONZÍKOVÁ Klára HRSTKOVÁ Hana HONZÍKOVÁ Nataša ZÁVODNÁ Eva FIŠER Bohumil HONZÍK Petr

Year of publication 2010
Type Article in Periodical
Magazine / Source Physiological Research
MU Faculty or unit

Faculty of Medicine

Citation
Field Physiology
Keywords anthracyclines; blood pressure; cardiotoxicity; childhood cancer; chronobiology
Description In our previous studies, a decreased blood pressure was reported in children treated by anthracycline (AC). The aim of this study was to assess the long-term effects of AC anticancer therapy in 45 subjects aged 13-22 years by repeated 24-hour Holter monitoring of blood pressure.It is concluded that blood pressure in 19-22 years old AC patients is lower during night hours, the age-dependent increase of blood pressure seen in healthy controls between 13 and 22 years of age does not occur in patients. This finding is consistent with the long-lasting impairment of the sympathetic nervous system caused by anthracyclines.
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