Interlaboratory study of free monoclonal immunoglobulin light chain quantification

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Authors

VÁVROVÁ Jaroslava MAISNAR Vladimír TICHÝ Miloš FRIEDECKÝ Bedřich ČERMÁKOVÁ Zdeňka DASTYCH Milan GOTTWALDOVÁ Jana KUČERA Petr KROTKÁ Jarmila RACEK Jaroslav ŽENKOVÁ Jana SCHNEIDERKA Petr LOCHMAN Pavel ZIMA Tomáš BEŇÁKOVÁ Hana BÜCHLER Tomáš SPÁČILOVÁ Jana HÁJEK Roman PALIČKA Vladimír

Year of publication 2011
Type Article in Periodical
Magazine / Source Clinical Chemistry and Laboratory Medicine
MU Faculty or unit

Faculty of Medicine

Citation
Doi http://dx.doi.org/10.1515/CCLM.2011.019
Field Oncology and hematology
Keywords interlaboratory comparison; monoclonal free light chains; monoclonal gammopathy; multiple myeloma; standardisation
Description The study revealed several weak points in the methodology, including the need for a uniform sample dilution procedure. Interlaboratory reproducibility was comparable with values achieved in the NEQAS programme. Because the kappa/lambda ratio cannot be measured with high precision, kappa and lambda FLC concentrations should be used where possible. Due to its impact on the clinical management of patients with gammopathy, FLC quantification needs to become a part of the regular quality control cycle in myeloma centres.
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