Projevy histiocytózy z Langerhansových buněk v orofaciální oblasti

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Title in English Langerhans cell histiocytosis (LCH) in orofacial region
Authors

FASSMANN Antonín IZAKOVIČOVÁ HOLLÁ Lydie AUGUSTÍN Peter VOKURKA Jan VANĚK Jiří

Year of publication 2010
Type Article in Periodical
Magazine / Source Vnitřní lékařství
MU Faculty or unit

Faculty of Medicine

Citation
Field ORL, ophthalmology, stomatology
Keywords Langerhans cell histiocytosis; histiocytosis X; oral manifestation; infiltrate; bone lesion
Description Langerhans cell histiocytosis (LCH) is a rare disease of unknown origin. It is characterized by intense and abnormal proliferation of bone marrow-derived histiocytes (Langerhans cells). This disease has a broad spectrum of forms and severity of clinical manifestations, it invades bones, skin, mucosa as well as the inner organs. This case report describes a 33-year monitoring of a patient with a chronic diffuse form of LCH, so called Hand-Schüller-Christian disease. Apart from skin manifestations, this patient also had infiltrates of the oral mucosa, and osteolytic lesions of the alveolar bone of both upper and lower jaws. These findings helped dermatologists confirm the diagnosis of LCH The dentist plays an important role in multidisciplinary treatment of patients with LCH as periodic checkups with emphasis on possible oral manifestations can reveal the first signs of LCH.
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