Comparison of Voltage-Sensitive Dye di-4-ANEPPS Effects in Isolated Hearts of Rat, Guinea Pig, and Rabbit

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Authors

FIALOVÁ Kateřina KOLÁŘOVÁ Jana PROVAZNÍK Ivo NOVÁKOVÁ Marie

Year of publication 2010
Type Article in Periodical
Magazine / Source Computing in Cardiology
MU Faculty or unit

Faculty of Medicine

Citation
Web http://cinc2010.org
Field Physiology
Keywords isolated heart; voltage-sensitive dye; arrhythmia; rat; guinea pig; rabbit
Description Voltage sensitive dyes (VSDs) are used for recording of monophasic action potentials (MAPs) by optical method in excitable tissues. Their direct effect on the tissue are not completely elucidated. Previously we studied effects of VSD di-4-ANEPPS during staining and washout in Langendorff-perfused guinea pig and rabbit isolated hearts. However, most often used species in basic cardiology is rat. Therefore, we decided to compare the electrophysiological effects of VSD in isolated hearts of rabbit, guinea pig, and rat.
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