Ecotoxicity and genotoxicity assessment of cytotoxic antineoplastic drugs and their metabolites

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Authors	ZOUNKOVÁ Radka KOVALOVÁ Lubomíra BLÁHA Luděk DOTT Wolfgang
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Chemosphere
MU Faculty or unit	Faculty of Science
Citation
Field	Environment influence on health
Keywords	Cytostatics; Cytotoxic drugs; Metabolites; Ecotoxicity; Cenotoxicity; Chronic effects
Description	This study reported ecotoxicity and genotoxicity of three widely used cytostatic agents (5-fluorouracil (5-FU), cytarabine (CYT) and gemcitabine (GemC) and their major human metabolites, i.e. alpha-fluoro-beta-alanine (FBAL), uracil-1-beta-D-arabinofuranoside (AraU) and 2',2'-difluorodeoxyuridine (dFdU)).
Related projects:	Interactions among the chemicals, environment and biological systems and their consequences on the global, regional and local scales (INCHEMBIOL) Centrum pro výzkum toxických látek v prostředí