Regrese osteolytického ložiska u pacienta s mnohočetným myelomem léčeného klodronátem po úspěšné terapii režimem s bortezomibem

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Title in English Regression of an Osteolytic Lesion in Patient with Multiple Myeloma Treated with Clodronate after a Successful Therapy with Bortezomib-based Regimen
Authors

SZTURZ Petr JAKUBCOVÁ R. ADAM Zdeněk KLINCOVÁ Mária KREJČÍ Marta POUR Luděk ZAHRADOVÁ Lenka HÁJEK Roman MAYER Jiří

Year of publication 2011
Type Article in Periodical
Magazine / Source Klinická onkologie
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords ;multiple myeloma; bortezomib; bisphosphonates; osteolysis; osteogenesis; radiography
Description Osteolytic lesions are a common manifestation of multiple myeloma, though their healing is rare in these patients. Generally, during a complete remission, lesions only stop progressing; radiologically evident recalcification is exceptional. Herein we report a case of a male patient born in 1941 and diagnosed in 2005 with IgA multiple myeloma presenting with multiple osteolytic bone lesion. A complete remission of the disease after an administration of bortezomib (Velcade) based regimen in long-term clodronate (Bonefos) treated patient with relapsed multiple myeloma is radiographically apparent by clear healing signs of the osteolytic bone lesion.
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