Účinnost a bezpečnost podávání moxonidinu u pacientů s metabolickým syndromem (klinické hodnocení O.B.E.Z.I.T.A.)

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Title in English The efficacy and safety of moxonidine in patients with metabolic syndrome (the O.B.E.Z.I.T.A. trial)
Authors

KRUPIČKA Jiří SOUČEK Miroslav CHROUST K.

Year of publication 2011
Type Article in Periodical
Magazine / Source Vnitřní lékařství
MU Faculty or unit

Faculty of Medicine

Citation
Field Endocrinology, diabetology, metabolism, nutrition
Keywords metabolic syndrome; uncontrolled hypertension; metabolically neutral products; obesity; clinical trial
Description Tratment with agents neutral to lipid metabolism but with a positive effect on glucose metabolism might significantly improve ther long-term prognosis of patients with metabolic syndrome and hypertension. The aim of our non-interventional observational clinical study was to evaluate the safety of treatment with moxonidine and to assess changes to the metabolic syndrome-related laboratory parameters. Over the 6-month follow up, a highly significant change was observed to all monitored parameters. An addition of monoxidine to an existing treatment resulted not only in a reduction to blood pressure but also in highly significant changes to metabolic parameters without any significant modifications of the treatment. Treatment with monoxidine can be considered as metabolically neutral with an added value of positive effect on metabolic parameters. This is a line with the results of other studies.
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