Systemic administration of D2 antagonist raclopride inhibits CYP1A2 in the rat model of isolated perfused liver

• Authors: JUŘICA Jan; ZENDULKA Ondřej; TRUBAČ Roman; ŠULCOVÁ Alexandra
• Year of publication: 2011
• Type: Article in Periodical
• Magazine / Source: Activitas Nervosa Superior Rediviva
• MU Faculty or unit: Central European Institute of Technology
• Web: http://www.rediviva.sav.sk/53i1/32.pdf
• Field: Pharmacology and pharmaceutical chemistry
• Keywords: raclopride; cytochrome P450; isolated perfused rat liver
• Description: Our study addressed whether systemic administration of raclopride (D2 receptor antagonist) may influence the metabolic activity of rat CYP1A2, CYP2C6/11 or CYP2D2 in the model of isolated perfused liver. It was taken into consideration that CYP2C6/11 is a rat orthologue of human CYP2C9 (Matuskova et al 2009), CYP2D1 is rat orthologue of human CYP2D6 (Soucek & Gut 1992). The most used marker of CYP2D6 dextromethorphan is metabolized by CYP2D2 in rats (Kobayashi et al 2002). The model of isolated perfused rat liver was selected because it reflects most of physiological and biochemical linkages in the liver-mediated metabolism of xenobiotics

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