Lack of association between the Val158Met catechol-O-methyltransferase gene polymorphism and methamphetamine dependence

Warning

This publication doesn't include Faculty of Arts. It includes Faculty of Science. Official publication website can be found on muni.cz.

Authors	HOSÁK Ladislav ŠERÝ Omar BERÁNEK Martin ALDA Martin
Year of publication	2011
Type	Article in Periodical
Magazine / Source	Neuroendocrinology Letters
MU Faculty or unit	Faculty of Science
Citation
Field	Psychiatry, sexuology
Keywords	methamphetamine dependence; Val158Met catechol-O-methyltransferase polymorphism; population-based genetic association study; family-based genetic association study; psychotic disorder
Description	We did not find any significant association between the Val158Met catechol-O-methyltransferase gene polymorphism and methamphetamine dependence using the population-based or family-based design (p=0.41–0.66; Chi-Square Test or UNPHASED program, Version 3.1.4, respectively). We found a trend toward a statistically significant difference between the Val allele carriers and Met/Met homozygotes in the frequence of psychotic symptoms induced by methamphetamine (more frequent in Val carriers; p=0.062; Chi-Square Test).
Related projects:	Genetic study of alcohol dependence : detection of the association between candidate gene polymorphisms and alcoholism.