Srovnání vlivu systémové premedikace, akutního podání a intracerebrální aplikace D2 antagonisty raclopridu na metabolickou aktivitu vybraných isoforem CYP450 u potkana

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Title in English	Comparison of the influence of systemic premedication, acute administration and intracerebral administration of D2 antagonist raclopride on the metabolic activity of selected CYP450 enzymes in rats
Authors	JUŘICA Jan ZENDULKA Ondřej ŠULCOVÁ Alexandra
Year of publication	2011
Type	Conference abstract
MU Faculty or unit	Central European Institute of Technology
Citation
Description	Raclopride is a D2 dopaminergic antagonist. Dopaminergic pathways are known to interfere with the activity of liver biotransforming enzymes. This work aimed to reveal the differences in metabolic activity of 2D2, 2C6/11 and 1A2 isoenzymes of cytochrome P450 after various kinds of raclopride administration in rats. Some differences in CYP metabolic aktivity were identified in CYP1A2 and CYP2D6, differences were observed also within the groups of animals administered intracerebrally, intraperitoneally or acute administration in the model of isolated perfused liver.
Related projects:	The internal organisation and neurobiological mechanisms of functional CNS systems under normal and pathological conditions.