Mezilaboratorní studie stanovení volných monoklonálních lehkých řetězců imunoglobulinů

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Title in English	Comparison of results of monoclonal free immunoglobulin light chains quantification in the serum in clinical laboratories in the Czech Republic
Authors	VÁVROVÁ J. TICHÝ M. FRIEDECKÝ B. MAISNAR Vladimír HÁJEK Roman ČERMÁKOVÁ Z. DASTYCH M. GOTTWALDOVÁ J. KUČERA P. KROTKÁ J. RACEK J. ŽENKOVÁ J. SCHNEIDERKA P. LOCHMAN P. BÜCHLER Tomáš ZIMA T. BENÁKOVÁ H. SPÁČILOVÁ J. PALIČKA V.
Year of publication	2010
Type	Article in Periodical
Magazine / Source	Klinická biochemie a matabolismus
MU Faculty or unit	Faculty of Medicine
Citation
Field	Oncology and hematology
Keywords	Interlaboratory comparison; Monoclonal free light chains; Monoclonal gammopathy; Multiple myeloma
Description	Free monoclonal immunoglobulin light chains (FLC) quantification is recommended for diagnosis assessment and monitoring therapy for patients with monoclonal gammopathy. But there are numerous uncertainties regarding the detection, interpretation and FLC quantification. Our interlaboratory study showed that kappa/lambda ratio is strongly influenced by measurement errors and therefore we recommended the preferential use of FLC concentration values. Unified protocols are needed to minimise interlaboratory variability introduced by manual dilution or volume augmentation of clinical sample.
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