CHANGES OF BLOOD PRESSURE BAROREFLEX REGULATION IN YOUNG TYPE-1 DIABETICS

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Authors

ZÁVODNÁ Eva HONZÍKOVÁ Nataša JAVORKA Michal JAVORKA Kamil TONHAJZEROVÁ Ingrid KRTIČKA Antonín

Year of publication 2011
Type Conference abstract
MU Faculty or unit

Faculty of Medicine

Citation
Description Our aim was to study the relationship between f and BRS during spontaneous variations and to evaluate the f and BRS relationship as a diagnostic test of autonomous nervous impairment in young T1DM. We monitored 14 T1DM (age 20-25 years, DM duration 10-15 years, the Michigan Neuropathy Screening Instrument did not reveal neuropathy in any patients) and 14 age-matched controls (Co). Blood pressure and heart rate were recorded beat-to-beat by Finapres for 40 minutes in supine position. BRS was determined by the spectral method, peak f of the cross spectra SBP x PI was determined in a 0.06 – 0.12 Hz range. Receiver operation curves (ROC) were calculated for f, BRS, and F(z). F(z) values were calculated from equations F(z)=1/(1+ exp(-z)), z=a+b1*BRS+b2*f. The ROC of f and the ROC of F(z)-values revealed 50% sensitivity with 100% specificity. The results indicate that the measurement of f and BRS can reveal subtle impairment of the autonomic nervous system where standard tests failed.
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