Studie SHIFT (the Systolic Heart Failure Treatment with the If Inhibitor Ivabradine Trial) a její přínos pro léčbu srdečního selhání

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Title in English The SHIFT study (Systolic Heart Failure Treatment with the If Inhibitor Ivabradine Trial) and its benefit for heart failure treatment
Authors

VÍTOVEC Jiří ŠPINAR Jindřich

Year of publication 2011
Type Article in Periodical
Magazine / Source Intervenční a akutní kardiologie
MU Faculty or unit

Faculty of Medicine

Citation
Field Cardiovascular diseases incl. cardiosurgery
Keywords heart failure; ivabradine; heart rate
Description The SHIFT study compared the effect of ivabradine with that of placebo in 6,558 patients with heart failure of ischaemic as well as nonischaemic aetiology, functional classification NYHA II-IV, with a resting heart rate above 70 bpm who received an optimal treatment for heart failure, including a maximum tolerated dose of beta blockers. The study has shown a significant reduction in the risk of the primary endpoint of cardiovascular mortality and hospitalization for heart failure by 18% in the group treated with ivabradine. Also, there was a decrease in the risk of death from heart failure by 26% in the active treated group. The decrease in hospitalization rate for heart failure was similar. Ivabradine was well tolerated with minimal side effects.
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