Prognóza vysoko rizikovej skupiny monoklonálnej gamapatie nejasného významu (MGUS) a asymptomatického mnohopočetného myelómu (SMM)

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Title in English Prognosis of high-risk group of monoclonal gammopathy of undetermineted significance (MGUS) and smoldering multiple myeloma (SMM)
Authors

KLINCOVÁ Mária MIKULÁŠOVÁ Aneta KOVÁŘOVÁ Lucie SANDECKÁ Viera RADOCHA Jakub MAISNAR Vladimír ADAM Zdeněk KREJČÍ Marta POUR Luděk ZAHRADOVÁ Lenka KŘIVANOVÁ Andrea SZTURZ Petr HÁJEK Roman

Year of publication 2011
Type Article in Periodical
Magazine / Source Onkologie
MU Faculty or unit

Faculty of Medicine

Citation
Field Oncology and hematology
Keywords monoclonal gammopathy of undeterminated significance; asymptomatic form of multiple myeloma; prognosis; progression
Description Monoclonal gammopathy of undeterminated significance (MGUS) and asymptomatic form of myeloma are associated with a long-term risk of progression to active disease symptomatic multiple myeloma or related malignancy. As far as the malignant transformation of MGUS is concerned, size and type of the serum monoclonal immunoglobulin (monoclonal protein, M-protein, M-Ig), serum kappa and lambda free light chain ratio, number of clonal plasma cells in bone marrow, number of clonal plasma cells in peripheral blood, immunophenotype of plasma cells, and another factors seem to play a predictive role.
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